Scientific Background Diacetyl Boldine
It is a derivative of Boldine and synthesized from the latter, it is a skin depigmentant that is nowadays used in various cosmetic formulations. Pérez y del Pozo (2006) points out that Diacetyl boldine delays melanin synthesis, clarifying and illuminating the epidermis.
Pratchyapurit (2016), studied Diacetil boldina in different formulations to determine the concentration of the compound. The research was conducted on patients (arm and face), of whom they had no side effects or adverse effects, so the initial N was the same as the final N. In addition, they emphasize that these new formulations have the benefit of being a better choice than hydroquinone that is used as a depigmentant. They conclude that by adding Diacetil boldina in sunscreen formulations, it facilitates use for people with melasma.
Khmaladze, et al (2019) conducted in vitro and ex vitro studies with Diacetil boldina and noted that the compound inhibits the production and synthesis of melanin, slowing skin aging, supporting use in cosmetic formulations.
This compound synthesized from Boldine is used in cosmetic formulations for anti-aging and skin darkening prevention. There are several products on the market that contain Diacetil boldina, which have protection of international patents available in this link.